Bioequivalence of Two Brands of Gentamicin Injection in Goats
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چکیده
Bioequivalence of two brands of gentamicin injection were studied in twelve clinically healthy goats. Single dose, equivalent to 5 mg gentamicin/kg.b.wt. was administered intramuscular to the subjects in a parallel two way crossover design. The studied non-innovator brand (Opigent 10%) were biologically equivalence with Garamicin 4% as innovator (no statistically significant difference were observed using ANOVA at p≤0.05) in any in vivo indicator of the bioequivalence parameters, where, the area under plasma concentration-time curve (AUC00-24) was 118.14±3.36 and 118.12±4.75 μg/ml.h and maximum plasma concentration (Cmax) was 18.68±0.09 and 18.77±1.00 μg/ml for the studied innovator and noninnovator consequently.
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